Studies that suggest that certain viral infections can influence the start of the diseases of Alzheimer’s receive attention. In this context, a domestic research team has succeeded in breaking the relationship between viral infection and Alzheimer’s disease using a new candidate for treatment.
Dr. Ok Sarah Shin, professor in the Department of Convergence Medicine at the Korea University College of Medicine (KUCM), leads the research team together with Dr. Soo-Jin Oh from KUCM and Professor Jean-Ho Yun from Dong-A University College of Medicine. Dr.’s team Shin has identified the association between viral infection and Alzheimer’s disease and blocked the connection using the new drug candidate Alt001.
Alzheimer’s disease is one of the most common types of dementia. Recent studies suggest that neurotrope viruses such as herpes simplex virus type 1 (HSV-1) can influence the development of neurodegenerative diseases. How HSV-1 infection accelerates neurodegenerative phenotypes is not clearly identified.
The research team first analyzed the effects of HSV-1 infection on Microglia, the immune cells of the brain. The use of various experimental systems, including mice, microglia derived from human microglia, microglia-neuron co-culture models and brain organoids (artificial mini-brain models)-they confirmed that HSV-1 infection disrupts mitophagia, the Intracellular CLASURE RIA, Mitochondria, BCA, BCABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE, BABE. Mitochondria, Mitochondria disturbs. The team has also shown that the infection interferes with phagocytosis, the process of cleaning up amyloid aggregate protein lumps that accumulate in the brain that can accelerate neurodegenerative diseases.
Based on these findings, the Mitophagy Enhancer Alt001, developed by the research team, showed effects on suppressing HSV-1 infection and the relief of neuro-inflammation. Alt001 improved mitophagia function in virus-infected microglia. As a result, it effectively braked the viral replication and reduced neuro -inflammatory reactions. It was also confirmed that it is the power of the microglia to erase amyloid aggregates.
Professor Shin stated: “This study is very important because it not only demonstrates at the molecular level that viral infection can deteriorate neurodegenerative diseases, including Alzheimer’s, but also presents a new treatment strategy, in particular identifying the impact of HSV-1 infection on Mitlia in Mitlia” Ovening. “
In the meantime, the findings of this study have recently been published in the prestigious international magazine TheranosticS (Impact Factor 12.4) Under the title: “Pharmacological targeting of mitophagia Via Alt001, Herpes Simplex Virus 1 improves mediated microglial inflammation and promotes amyloid beta phagocytosis by limiting the HSV1 infection.“
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Journal Reference:
Oh, sj, et Alt Alto. (2025). Pharmacological targeting of mitophagia Via Alt001 improves Herpes Simplex virus 1 (HSV1) -Memedated microglial inflammation and promotes amyloid β fagocytosis by limiting the HSV1 infection. Theranostics. doi.org/10.7150/thno.105953.